First Parish in Bedford has had over 30 senior ministers since 1730.
| Minister | Start | End |
|---|---|---|
| Nicholas Bowes | 1730 | 1754 |
| Nathaniel Sherman | 1755 | 1769 |
| Joseph Penniman | 1771 | 1793 |
| Samuel Stearns | 1796 | 1832 |
| A. Davis | 1833 | 1834 |
| Robert Walcott | 1834 | 1835 |
| Joshua Chandler | 1836 | 1842 |
| George W. Woodward | 1844 | 1846 |
| Jonas Whitman | 1846 | 1848 |
| William Cushing | 1849 | 1853 |
| George W. Webster | 1860 | 1861 |
| Grindall Reynolds | 1869 | 1874 |
| George Piper | 1884 | 1890 |
| Samuel Andrew Dyberg | 1890 | 1892 |
| Oliver J. Fairfield | 1893 | 1898 |
| Loren B. MacDonald | 1899 | 1920 |
| Hurley Begun | 1920 | 1922 |
| Roydon C. Leonard | 1922 | 1926 |
| Harland S. Evans | 1934 | 1937 |
| Anita Trueman Pickett | 1937 | 1942 |
| John White Eager | 1942 | 1944 |
| Gilbert A. Phillips | 1944 | 1947 |
| Richard Sechrist | 1947 | 1948 |
| M. O. Lovely | 1952 | 1953 |
| Oscar B. Hawes | 1953 | 1954 |
| David C. Pohl | 1954 | 1957 |
| Robert Henry Holmes | 1957 | 1964 |
| David R. Weissbard | 1965 | 1974 |
| William F. Schulz | 1975 | 1978 |
| Jack Mendelsohn | 1979 | 1988 |
| Douglas Morgan Strong | 1988 | 1990 |
| John E. Gibbons | 1990 | 2021 |
| Wendy L. Bell | 2021 | 2022 |
| Annie Gonzalez | 2022 | 2023 |
| Jamie Hinson-Rieger | 2023 |